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Tadalafil Pros. Tadalafil has a half-life of 17.5 hours — it remains active in your body for far longer than other ED medications. ... Sildenafil, tadalafil, vardenafil, and Stendra are all safe ...
As for how long it lasts, the packaging insert says Viagra has a half-life of four hours. ... In some cases, another ED drug — such as Cialis or its generic tadalafil, and Stendra or its generic ...
Cialis (tadalafil) has a half-life of 17.5 hours, meaning this drug lasts up to 36 hours after it’s consumed. Levitra (vardenafil) ...
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9] It is unclear if it is effective for treating sexual dysfunction in females. [8]
Although sildenafil, vardenafil, and tadalafil all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.5 hours), [21] compared to sildenafil and vardenafil, which are both 4–5 hours. [22] This translates to a longer duration of action, which is partly responsible for "The Weekend Pill" nickname.
Tadalafil (marketed as Cialis) is a PDE5 inhibitor used to treat erectile dysfunction [23] and pulmonary arterial hypertension. [24] It has a longer half life than sildenafil of 17.5 hours, allowing it to be taken once a day. [24] Tadalafil "daily" (5 mg) is also used for treatment of benign prostate hyperplasia. [25]