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Lercanidipine (trade name Zanidip, among others) is an antihypertensive (blood pressure lowering) drug. It belongs to the dihydropyridine class of calcium channel blockers , which work by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body.
A study in 2000 found that long-term benzodiazepine therapy does not result in brain abnormalities. [75] Withdrawal from high-dose use of nitrazepam anecdotally was alleged in 2001 to have caused severe shock of the whole brain with diffuse slow activity on EEG in one patient after 25 years of use. After withdrawal, abnormalities in hypofrontal ...
The first large study to show a mortality benefit from antihypertensive treatment was the VA-NHLBI study, which found that chlorthalidone was effective. [50] The largest study, Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) in 2002, concluded that chlorthalidone (a thiazide-like diuretic) was as effective ...
This is a general list of long-term side effects ... dyskinesia is significantly high and estimated to be a 20-50% ... was last edited on 9 ...
Calcium channel blocker toxicity is the taking of too much of the medications known as calcium channel blockers (CCBs), either by accident or on purpose. [3] This often causes a slow heart rate and low blood pressure. [1]
A fact from Lercanidipine appeared on Wikipedia's Main Page in the Did you know column on 11 August 2016 (check views). The text of the entry was as follows: Did you know... that grapefruit juice may amplify the antihypertensive effect of lercanidipine? A record of the entry may be seen at Wikipedia:Recent additions/2016/August.
Occupation of the S3 sp subpocket can increase potency by 50-fold and results in tight binding. [11] Example of binding to the renin inhibitor: Aliskiren is a peptide-like renin inhibitor and, unlike most, it is rather hydrophilic. It blocks the catalytic function of the enzyme by occupying the S3 to S2′ pockets, except the S2 pocket.
For over a thousand years South American indigenous peoples have chewed Erythroxylon coca leaves, which contain alkaloids such as cocaine. Coca leaf remains have been found with ancient Peruvian mummies. [21] There is also evidence coca leaves were used as an anesthetic. [22]