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Hershey and Chase concluded that DNA, not protein, was the genetic material. They determined that a protective protein coat was formed around the bacteriophage, but that the internal DNA is what conferred its ability to produce progeny inside a bacterium. They showed that, in growth, protein has no function, while DNA has some function.
Experiments conducted in 1952 by Alfred Hershey and Martha Chase demonstrated how the DNA of viruses is injected into the bacterial cells, while most of the viral proteins remain outside. [1] [2] The injected DNA molecules cause the bacterial cells to produce more viral DNA and proteins. These discoveries supported that DNA, rather than ...
In 1971, he edited The Bacteriophage λ, an extensive volume on the subject, published by CSHL Press that same year. [1] In 1981, Hershey became a founding member of the World Cultural Council. [9] Hershey died from congestive heart failure on May 22, 1997 at his home in Laurel Hollow, New York. [10] He was 88 years old.
In July 2007, the same bacteriophage were approved for use on all food products. [38] In 2011 USDA confirmed that LISTEX is a clean label processing aid and is included in USDA. [39] Research in the field of food safety is continuing to see if lytic phages are a viable option to control other food-borne pathogens in various food products. [40]
In 1952, Hershey and Chase [19] provided key evidence that the phage DNA, as distinct from protein, enters the host bacterial cell upon infection and is thus the genetic material of the phage. This finding suggested that DNA is, in general, the genetic material of different organisms.
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After the discovery of the structure of DNA in 1953, it was still unclear how DNA replicated. The favored model at the time was semi-conservative replication, but experimental proof was needed. The Meselson–Stahl experiment , [ 13 ] performed by Matthew Meselson and Franklin Stahl in 1958, was the key experiment that provided convincing ...
In 1952, Alfred Hershey and Martha Chase confirmed that the genetic material of the bacteriophage, the virus which infects bacteria, is made up of DNA [4] (see Hershey–Chase experiment). In 1953, James Watson and Francis Crick discovered the double helical structure of the DNA molecule based on the discoveries made by Rosalind Franklin. [5]