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Low-intensity pulsed ultrasound (LIPUS) is a technology that can be used for therapeutic purposes. It exploits low intensity and pulsed mechanical waves in order to induce regenerative and anti-inflammatory effects on biological tissues, such as bone, [ 1 ] cartilage, and tendon. [ 2 ]
Transcranial pulsed ultrasound (TPU) uses low intensity, low frequency ultrasound (LILFU) to stimulate the brain. In 2002, Dr. Alexander Bystritsky first proposed the idea that this methodology contained therapeutic benefits. [ 1 ]
Turning off ultrasound allows for hydrogel to restore its matrix. Of the existing ultrasound modalities, focused ultrasound has been used extensively in drug delivery research. [33] [34] High-Intensity Focused Ultrasound (HIFU) and Low-Intensity Focused Ultrasound are the two main techniques used in inducing drug release from smart hydrogels. [43]
An additional effect of low-intensity ultrasound could be its potential to disrupt the blood–brain barrier for drug delivery. [36] Transcranial ultrasound is being tested for use in aiding tissue plasminogen activator treatment in stroke patients in the procedure called ultrasound-enhanced systemic thrombolysis.
A low intensity (ISPTA < 5 W/cm2) pulsed ultrasound (LIPSA) approach can exploit the mechanical properties of neoplastic cells to target them for destruction. Ultrasound applied at a frequency of 0.5–0.67 MHz for >20 ms causes selective disruption of a panel of breast, colon, and leukemia cancer cell models in suspension without significantly damaging healthy immune or red blood cells.
LILFU stands for low intensity, low frequency ultrasound. [1] It is a new technique devised by the team of William J. Tyler from Arizona State University to manipulate neuronal circuits using transcranial pulsed ultrasound. This could make the need of invasive (surgical) neuromodulation for some treatments and therapies unnecessary.
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