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The technique for thermal ablation in the lung by using radiofrequency ablation was first described in 1995 for use in animal lung tumor models and then in 2000 in humans. [1-2] Microwave ablation has emerged as a newer ablation modality and an addition to the arsenal of minimally invasive cancer care.
Radiofrequency ablation (RFA), also called fulguration, [1] is a medical procedure in which part of the electrical conduction system of the heart, tumor, sensory nerves or a dysfunctional tissue is ablated using the heat generated from medium frequency alternating current (in the range of 350–500 kHz).
Ablation techniques can be performed throughout the body such as in the lung, [7] liver, [8] [9] kidney, [10] prostate, [11] breast, [12] bone, [13] and other organs using image guidance to place a needle/probe through the skin into the target tissue.
Various local ablation therapies exist to induce necrosis of tumor cells and release tumor antigens to stimulate an immunological response. These ablation therapies can be combined with a systemic immunotherapy: Thermal ablation – local thermal ablation of tumor: Cryoablation; Radiofrequency ablation; High-intensity focused ultrasound ablation
In medicine, ablation is the removal of a part of biological tissue, usually by surgery. Surface ablation of the skin (dermabrasion, also called resurfacing because it induces regeneration) can be carried out by chemicals (chemoablation), by lasers (laser ablation), by freezing (cryoablation), or by electricity (fulguration).
This skin cancer tends to grow slowly and isn’t life-threatening for most people, but it needs to be treated before it can grow deep and injure nerves and blood vessels, the AAD noted.
IRE has been in use against prostate cancer since 2011, partly in form of clinical trials, compassionate care or individualized treatment approach. As for all other ablation technologies and also most conventional methods, no studies employed a randomized multi-center approach or targeted cancer-specific mortality as endpoint.
Cryoablation has been explored as an alternative to radiofrequency ablation in the treatment of moderate to severe pain in people with metastatic bone disease.The area of tissue destruction created by this technique can be monitored more effectively by CT than RFA, a potential advantage when treating tumors adjacent to critical structures.
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