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However, randomized trials like the Beta-Carotene and Retinol Efficacy Trial (CARET) [22] and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) [23] revealed not only a lack of benefit but an increased risk of cancer, particularly lung cancer among smokers. These findings prompted a reevaluation of antioxidant ...
The study was done using supplements and researchers were aware of the epidemiological correlation between carotenoid-rich fruits and vegetables and lower lung cancer rates. The research concluded that no reduction in lung cancer was found in the participants using these supplements, and furthermore, these supplements may, in fact, have harmful ...
β-Carotene (beta-carotene) is an organic, strongly colored red-orange pigment abundant in fungi, [7] plants, and fruits. It is a member of the carotenes , which are terpenoids (isoprenoids), synthesized biochemically from eight isoprene units and thus having 40 carbons .
Vitamin A is a fat-soluble vitamin that is an essential nutrient.The term "vitamin A" encompasses a group of chemically related organic compounds that includes retinol, retinyl esters, and several provitamin (precursor) carotenoids, most notably β-carotene (beta-carotene).
High doses of some antioxidants may have harmful long-term effects. The Beta-Carotene and Retinol Efficacy Trial (CARET) study of lung cancer patients found that smokers given supplements containing beta-carotene and vitamin A had increased rates of lung cancer. [140] Subsequent studies confirmed these adverse effects. [141]
C cell – c-erbB-2 – c-kit – CA 19-9 assay – CA-125 – CA-125 test – cachexia – calcitonin – calcitriol – CAM – Campath-1H – camptothecin – camptothecin analog – cancer – cancer induction – Cancer Information Service – cancer of unknown primary origin – cancer stem cell – cancer vaccine – Cancer.gov – Candidiasis – Candidosis – CAP-1 – capecitabine ...
In 1930, Paul Karrer elucidated the correct structure for beta-carotene, the main precursor of vitamin A, and identified other carotenoids. Karrer and Norman Haworth confirmed Albert Szent-Györgyi's discovery of ascorbic acid and made significant contributions to the chemistry of flavins , which led to the identification of lactoflavin .
Ching-Shih Chen (US), the former chair of cancer research at Ohio State University, was investigated by OSU and the federal Office of Research Integrity after being anonymously reported for falsifying data. The investigation found that Chen mishandled images and figures in published papers, "intentionally falsified data", and did not keep any ...