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  2. Melatonin as a medication and supplement - Wikipedia

    en.wikipedia.org/wiki/Melatonin_as_a_medication...

    Melatonin may be useful in the treatment of delayed sleep phase syndrome. [9] Melatonin is known to reduce jet lag, especially in eastward travel. However, if it is not taken at the correct time, it can instead delay adaptation. [30] Melatonin appears to have limited use against the sleep problems of people who work shift work. [31]

  3. Antidepressant discontinuation syndrome - Wikipedia

    en.wikipedia.org/wiki/Antidepressant...

    Venlafaxine has also been implicated to create withdrawal symptoms regardless of dosage. [15] Venlafaxine has been implicated in causing the most severe withdrawal symptoms after cessation of use, possibly due to its short half-life. [16] To simplify identifying the principal signs and symptoms, the mnemonic FINISH may be used: Flu-like ...

  4. Melatonin - Wikipedia

    en.wikipedia.org/wiki/Melatonin

    Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.

  5. Why Storms Make You Sleepy: The Science Behind Pre-Storm ...

    www.aol.com/why-storms-sleepy-science-behind...

    Shifting weather patterns can also influence hormone levels, according to experts, including melatonin, the hormone that regulates sleep. Increased melatonin production during overcast or stormy ...

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  7. Depressant - Wikipedia

    en.wikipedia.org/wiki/Depressant

    It features a typical depressant withdrawal syndrome that mimics alcohol withdrawal. [123] Symptoms include delirium, tremor, anxiety, tachycardia, insomnia, hypertension, confusion, sweating, severe agitation which may require restraint, [124] auditory and visual hallucinations, and possibly death from tonic-clonic seizures.

  8. Drug withdrawal - Wikipedia

    en.wikipedia.org/wiki/Drug_withdrawal

    The symptoms from withdrawal may be even more dramatic when the drug has masked prolonged malnutrition, disease, chronic pain, infections (common in intravenous drug use), or sleep deprivation, conditions that drug abusers often develop as a secondary consequence of the drug. When the drug is removed, these conditions may resurface and be ...

  9. Agomelatine - Wikipedia

    en.wikipedia.org/wiki/Agomelatine

    Agomelatine acts as a highly potent and selective melatonin MT 1 and MT 2 receptor agonist (K i = 0.1 nM and 0.12 nM, respectively) and also as a relatively weak serotonin 5-HT 2B and 5-HT 2C receptor antagonist (K i = 660 nM and 631 nM, respectively; ~6,000-fold lower than for the melatonin receptors).