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It is an experimental proapoptotic drug [1] that has been shown to cause rapid weight loss in mice [2] and rhesus monkeys. [3] Its mechanism of action is to target specific blood vessels supplying adipose tissue with blood, cause the vessels to shrink and the fat cells fed by those vessels to undergo apoptosis . [ 4 ]
A risk–benefit ratio (or benefit-risk ratio) is the ratio of the risk of an action to its potential benefits. Risk–benefit analysis (or benefit-risk analysis) is analysis that seeks to quantify the risk and benefits and hence their ratio. Analyzing a risk can be heavily dependent on the human factor.
Quantitatively, it is the ratio given by the toxic dose divided by the therapeutic dose. A protective index is the toxic dose of a drug for 50% of the population (TD 50) divided by the minimum effective dose for 50% of the population (ED 50). A high protective index is preferable to a low one: this corresponds to a situation in which one would ...
Obesity dipped slightly in U.S. adults last year for the first time in more than a decade, a study found. The researchers suggested that might be due, in part, to the rise of weight loss drugs ...
We will keep pushing those in power for answers as the future of new-generation weight-loss drugs unfolds. Put simply, your decision to entrust us with your stories is what fuels our most ...
Levodopa, a drug used to treat Parkinson’s disease, has been shown to increase the risk for pathological gambling. Patients who receive the drug are also counseled on this potential side effect.
In pharmacokinetics, the drug accumulation ratio (R ac) is the ratio of accumulation of a drug under steady state conditions (i.e., after repeated administration) as compared to a single dose. The higher the value, the more the drug accumulates in the body. An R ac of 1 means no accumulation.
Doty has a long list of the ways she tried — and failed — to lose weight over the years: Richard Simmons, Weight Watchers, ‘90s fad drug fen-phen, lap band surgery, Tae Bo, Atkins, gastric ...