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The most common length of survival following diagnosis is 10 to 13 months (although recent research points to a median survival rate of 15 months), [98] [99] [8] with fewer than 1–3% of people surviving longer than five years. [2] [5] [100] In the United States between 2012 and 2016 five-year survival was 6.8%. [5]
The overall incidence rate of brain tumors in children is 6.2 per 100,000. [10] Glioblastomas are the most aggressive malignant glioma and make up approximately 47.7% of all gliomas, and are more commonly found in males. [10] [16] Their incidence rate is 3.23 per 100,000 people. [10] The 5-year survival rate for glioblastoma is only 6.8%. [10]
The age-adjusted incidence rate is 6.4 per 100,000 per year, and the death rate is 4.3 per 100,000 per year. The lifetime risk of developing brain cancer for someone born today is 0.60%. Only around a third of those diagnosed with brain cancer survive for five years after diagnosis.
Glioblastoma (GBM) is the most common and aggressive malignant brain tumor, accounting for about 15% of all primary malignant brain tumors.
Sarcomatous glioblastoma [1] Micrograph showing a gliosarcoma. Elastic van Gieson's stain. Specialty: Neuro-oncology: Usual onset: Between 40 and 60 years old [2] Prognosis: Five-year survival rate: 5.6% [2] Frequency ~215 new diagnoses per year (United States) [2]
The mean age at clinical presentation is 42. The age distribution includes children and has a wider range than other diffuse astrocytomas (diffuse WHO grade II astrocytoma, anaplastic astrocytoma, ordinary glioblastoma). [14] [15] [16] The giant-cell glioblastoma affects males more frequently (the M/F ratio is 1.6). [1]
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