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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
[10] [11] Two notable protein phosphatases are PP2A and PP2B. PP2A is involved in multiple regulatory processes, such as DNA replication, metabolism, transcription, and development. PP2B, also called calcineurin, is involved in the proliferation of T cells; because of this, it is the target of some drugs that seek to suppress the immune system. [9]
5518 51792 Ensembl ENSG00000105568 ENSMUSG00000007564 UniProt P30153 Q76MZ3 RefSeq (mRNA) NM_014225 NM_001363656 NM_016891 RefSeq (protein) NP_055040 NP_001350585 NP_055040.2 NP_058587 Location (UCSC) Chr 19: 52.19 – 52.23 Mb Chr 17: 21.17 – 21.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is ...
Policy number: This is a unique number assigned to your car insurance policy. This helps your company find your exact policy when you make changes or file a claim. ... Policy term: The policy term ...
I 1 PP2A has a highly acidic C-terminal tail and the N-terminus is leucine/isoleucine rich (Li et al., 1996). In the presence of physiological conditions of Mn 2+, I 1 PP2A can also associate with and stimulate the activity of PP1 but Mn 2+ also does not affect the inhibition of PP2A through I 1 PP2A, in vitro (Janssens & Goris, 2001).
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In insurance, incurred but not reported (IBNR) claims is the amount owed by an insurer to all valid claimants who have had a covered loss but have not yet reported it. Since the insurer knows neither how many of these losses have occurred, nor the severity of each loss, IBNR is necessarily an estimate.
Term vs. whole life insurance. With term life insurance, the policyholder chooses a period during which their policy is active — usually somewhere between 10 and 30 years. The policyholder pays ...