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Other side effects of estrogens include an increased risk of blood clots, cardiovascular disease, and, when combined with most progestogens, breast cancer. [1] In men, estrogens can cause breast development, feminization, infertility, low testosterone levels, and sexual dysfunction among others.
Adverse effects can also occur in the urinary, central or peripheral nervous, or musculoskeletal systems. [35] A review of clinical trials studying bioidentical progesterone use found that it was ineffective in managing vasomotor symptoms of menopause, but had mild and self-limiting side effects. [36]
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Rare but serious side effects include blood clots, liver damage, and cancer of the uterus. [7] EE is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. [7] It is a synthetic derivative of estradiol, a natural estrogen, and differs from it in various ways. [7]
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