Ads
related to: gene copy number analysis practice- Services
Pharmacokinetics, Immunogenicity
Biomarkers, Cell-Based Assays
- Contact
Submit the required details
to contact us.
- Speak to a Scientist
Our team of scientists look forward
to tackling your challenges
- Our Solutions
Read more about our technologies
and modern bioanalysis processes
- Services
Search results
Results From The WOW.Com Content Network
Copy number analysis is the process of analyzing data produced by a test for DNA copy number variation in an organism's sample. One application of such analysis is the detection of chromosomal copy number variation that may cause or may increase risks of various critical disorders.
This gene duplication has created a copy number variation. The chromosome now has two copies of this section of DNA, rather than one. Copy number variation (CNV) is a phenomenon in which sections of the genome are repeated and the number of repeats in the genome varies between individuals. [1]
Genetic analysis may be done to identify genetic/inherited disorders and also to make a differential diagnosis in certain somatic diseases such as cancer. Genetic analyses of cancer include detection of mutations, fusion genes, and DNA copy number changes. FDA microbiologist prepares DNA samples for gel electrophoresis analysis
MLPA has a variety of applications [5] including detection of mutations and single nucleotide polymorphisms, [6] analysis of DNA methylation, [7] relative mRNA quantification, [8] chromosomal characterisation of cell lines and tissue samples, [9] detection of gene copy number, [10] detection of duplications and deletions in human cancer ...
Array CGH has proven to be a specific, sensitive, fast and high-throughput technique, with considerable advantages compared to other methods used for the analysis of DNA copy number changes making it more amenable to diagnostic applications. Using this method, copy number changes at a level of 5–10 kilobases of DNA sequences can be detected. [15]
Structural variations, such as copy-number variation and deletions, inversions, insertions and duplications, account for much more human genetic variation than single nucleotide diversity. This was concluded in 2007 from analysis of the diploid full sequences of the genomes of two humans: Craig Venter and James D. Watson.
SNP arrays, however, have an additional advantage of being able to detect copy-neutral LOH (also called uniparental disomy or gene conversion). Copy-neutral LOH is a form of allelic imbalance. In copy-neutral LOH, one allele or whole chromosome from a parent is missing. This problem leads to duplication of the other parental allele.
Copy number variation is a very important type of structural variation and has been studied extensively. A study on the influence of the CCL3L1 gene on HIV-1/AIDS susceptibility tested if the copy number of the CCL3L1 gene had any effect on an individual’s susceptibility to HIV-1