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Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures [7] and essential tremors. [8] It is taken by mouth. [7] Its common side effects include sleepiness, poor coordination, nausea, and loss of appetite. [7] Severe side effects may include suicide and ...
A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. [1] [2] Instead of administering a drug directly, a corresponding prodrug can be used to improve how the drug is absorbed, distributed, metabolized, and excreted ().
Primidone: may accelerate metabolism of valproate, leading to a decline of serum levels and potential breakthrough seizure. Rifampicin: increases the clearance of valproate, leading to decreased valproate concentrations. Warfarin: valproate may increase free warfarin concentration and prolong bleeding time.
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Of note, although Mindfulness-based cognitive therapy for depression prevented relapse of future depressive episodes, there is no research on whether it can cause the remission of a current depressive episode. [35] Interpersonal psychotherapy (IPT) focuses on the social and interpersonal triggers that may cause depression. There is evidence ...
"Depression" refers to a spectrum of disturbances in mood that vary from mild to severe and from short periods to constant illness. [1] DD-NOS is diagnosed if a patient's symptoms fail to meet the criteria more common depressive disorders such as major depressive disorder or dysthymia .
Here are links to possibly useful sources of information about Primidone. PubMed provides review articles from the past five years (limit to free review articles ) The TRIP database provides clinical publications about evidence-based medicine .
"The Hamilton Rating Scale for Depression" (PDF). Archived from the original (PDF) on 2007-11-20 (49.0 KB) Clinically Useful Psychiatric Scales: HAM-D (Hamilton Depression Rating Scale). Accessed March 6, 2009. Hamilton Depression Rating Scale - Original scientific paper published in 1960 in Psychiatry out of Print website. Accessed June 27, 2008.
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