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  2. Lidocaine - Wikipedia

    en.wikipedia.org/wiki/Lidocaine

    Lidocaine is an antiarrhythmic medication of the class Ib type. [8] This means it works by blocking sodium channels thus decreasing the rate of contractions of the heart. [11] [8] When injected near nerves, the nerves cannot conduct signals to or from the brain. [9] Lidocaine was discovered in 1946 and went on sale in 1948. [12]

  3. Transdermal analgesic patch - Wikipedia

    en.wikipedia.org/wiki/Transdermal_analgesic_patch

    The lidocaine patch is proven to reduce acute or short-term pain after surgeries or procedures at rest. There has been no proven decreased opioid use from lidocaine patches. There has been no research regarding specific procedures and the effects of transdermal lidocaine, but the efficacy of lidocaine is considered minor. [8]

  4. First pass effect - Wikipedia

    en.wikipedia.org/wiki/First_pass_effect

    First-pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and nitroglycerin) or in the gut (for benzylpenicillin and insulin). [4] The four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, [5] gastrointestinal wall enzymes, [6] [7] [8] bacterial enzymes [5] and hepatic enzymes.

  5. Guys: Looking for a "Downstairs" Numbing Cream? Here's ... - AOL

    www.aol.com/lifestyle/guys-looking-downstairs...

    If you have early climax (PE), you may have heard that selective serotonin reuptake inhibitors (SSRIs) and topical creams and sprays with lidocaine can help you manage your symptoms.

  6. Nephrotoxicity - Wikipedia

    en.wikipedia.org/wiki/Nephrotoxicity

    Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.

  7. Dermal patch - Wikipedia

    en.wikipedia.org/wiki/Dermal_patch

    Lidocaine patches, marketed as Lidoderm, relieve the peripheral pain of shingles (herpes zoster). It became commonly used off-label, for pain from acute injuries and chronic pain, although limited by its requirement to be removed for 12 hours, after 12 hours of use.

  8. Topical medication - Wikipedia

    en.wikipedia.org/wiki/Topical_medication

    A medical professional administering nose drops Instillation of eye drops. A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. [1]

  9. Hereditary leiomyomatosis and renal cell cancer syndrome

    en.wikipedia.org/wiki/Hereditary_leiomyomatosis...

    Drugs which affect smooth muscle contraction, such as doxazosin, nitroglycerine, nifedipine and phenoxybenzamine, may provide pain relief. Uterine fibroids can be treated with the same methods as sporadic uterine fibroids including anti-hormonal treatment, surgery, or embolisation .