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Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. It is frequently asymptomatic ; if symptoms appear, they typically begin 3 to 14 days after infection.
Dengue virus (DENV) is the cause of dengue fever.It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. [1] [2] Four serotypes of the virus have been found, and a reported fifth has yet to be confirmed, [3] [4] [5] all of which can cause the full spectrum of disease. [1]
Dengue fever becomes more virulent during a second infection by means of antibody-dependent enhancement. After the first infection, macrophages display antibodies on their cell membranes specific to the dengue virus. By attaching to these antibodies, dengue viruses from a second infection are better able to infect the macrophages, thus reducing ...
Dengue fever (UK: / ˈ d ɛ ŋ ɡ eɪ / or US: / ˈ d ɛ ŋ ɡ iː /), also known as breakbone fever, is an infectious tropical disease caused by the dengue virus. Symptoms include fever , headache , myalgias and arthralgias , and a characteristic skin rash that is similar to measles .
Dengue vaccine is a vaccine used to prevent dengue fever in humans. [9] Development of dengue vaccines began in the 1920s but was hindered by the need to create immunity against all four dengue serotypes. [10] As of 2023, there are two commercially available vaccines, sold under the brand names Dengvaxia and Qdenga. [11] [12]
Immune tolerance in pregnancy or maternal immune tolerance is the immune tolerance shown towards the fetus and placenta during pregnancy. This tolerance counters the immune response that would normally result in the rejection of something foreign in the body, as can happen in cases of spontaneous abortion .
In Latin America, 2019 was a record-setting dengue fever outbreak, with more than 2.7 million cases and 1206 deaths during the first 10 months of 2019. [25] [26] As of 2023, cases and Deaths of dengue fever reached up to 3 million cases and 1302 deaths.
President Benigno Aquino III at the launching of the dengue vaccine school-based immunization program. In April 2016, the DOH launched the dengue vaccination campaign in Central Luzon, Calabarzon and Metro Manila, where about 700,000 individuals received at least one dose of the vaccine. [11] The government paid P3.5-billion for the vaccine. [10]