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Lipid droplets, also referred to as lipid bodies, oil bodies or adiposomes, [1] are lipid-rich cellular organelles that regulate the storage and hydrolysis of neutral lipids and are found largely in the adipose tissue. [2] They also serve as a reservoir for cholesterol and acyl-glycerols for membrane formation and maintenance.
The first step is synthesizing the backbone (sphingosine or glycerol), the second step is the addition of fatty acids to the backbone to make phosphatidic acid. Phosphatidic acid is further modified with the attachment of different hydrophilic head groups to the backbone. Membrane lipid biosynthesis occurs in the endoplasmic reticulum membrane ...
In some cases, the hydrated region can extend much further, for instance in lipids with a large protein or long sugar chain grafted to the head. One common example of such a modification in nature is the lipopolysaccharide coat on a bacterial outer membrane. [10] TEM image of a bacterium. The furry appearance on the outside is due to a coat of ...
Vesicular cargoes move relatively fast (50–400 mm/day) whereas transport of soluble (cytosolic) and cytoskeletal proteins takes much longer (moving at less than 8 mm/day). [7] The basic mechanism of fast axonal transport has been understood for decades but the mechanism of slow axonal transport is only recently becoming clear, as a result of ...
The phase behavior of lipid bilayers is largely determined by the strength of the attractive Van der Waals interactions between adjacent lipid molecules. The extent of this interaction is in turn governed by how long the lipid tails are and how well they can pack together. Longer tailed lipids have more area over which to interact, increasing ...
The surface of a curved lipid bilayer. Lipidology is the scientific study of lipids. Lipids are a group of biological macromolecules that have a multitude of functions in the body. [1] [2] [3] Clinical studies on lipid metabolism in the body have led to developments in therapeutic lipidology for disorders such as cardiovascular disease. [4]
In the last step, monoacylglycerol is hydrolyzed to make glycerol and this is catalyzed by monoacylglycerol lipase (MGL). Example of a triacylglycerol. Lipolysis / l ɪ ˈ p ɒ l ɪ s ɪ s / is the metabolic pathway through which lipid triglycerides are hydrolyzed into a glycerol and free fatty acids.
The omegasome is a cell organelle consisting of lipid bilayer membranes enriched for phosphatidylinositol 3-phosphate (abbreviated PI(3)P or PtdIns3P), and related to a process of autophagy. [1] It is a subdomain of the endoplasmic reticulum (ER), [2] and has a morphology resembling the Greek capital letter Omega (Ω).