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Nitrates used in agricultural fertilizers may leak into the ground and may contaminate well water. The current EPA standard of 10 ppm nitrate-nitrogen for drinking water is specifically set to protect infants. [13] Benzocaine applied to the gums or throat (as commonly used in baby teething gels, or sore throat lozenges) can cause methemoglobinemia.
The structure of cytochrome b5 reductase, the enzyme that converts methemoglobin to hemoglobin. [1]Methemoglobin (British: methaemoglobin, shortened MetHb) (pronounced "met-hemoglobin") is a hemoglobin in the form of metalloprotein, in which the iron in the heme group is in the Fe 3+ state, not the Fe 2+ of normal hemoglobin.
A methemoglobin level > 1.5 g/dL causes cyanosis. The most common congenital cause is a deficiency in the enzyme cytochrome b5 reductase which reduces methemoglobin in the blood. [22] However, in infants the most common cause of methemoglobinemia is acquired through the ingestion of nitrates (NO − 3) through well water or foods.
The unpicked fruit of the coffee tree, known as the coffee cherry, undergoes a long process to make it ready for consumption. This process often entails use of large quantities of water and the production of considerable amounts of solid and liquid waste. The type of waste is a result of the type of process that the coffee cherries go through.
The most common and successful treatment used to treat patients with high levels of methemoglobinemia is the antidote methylene blue. Methylene blue is already recognized as a product of the reversible reaction fueled by NAPHD methemoglobin reductase, catalyzed by leukcomethylene, to reduce methemoglobin to hemoglobin.
Nitrate levels above 10 mg/L (10 ppm) in groundwater can cause 'blue baby syndrome' (acquired methemoglobinemia). [83] The nutrients, especially nitrates, in fertilizers can cause problems for natural habitats and for human health if they are washed off soil into watercourses or leached through soil into groundwater. [84]
Used coffee grounds is the result of brewing coffee, and are the final product after preparation of coffee. Despite having several highly-desirable chemical components, used coffee grounds are generally regarded as waste, and they are usually thrown away or composted. As of 2019, it was estimated that over 15 million tonnes of spent coffee ...
However, methemoglobin has increased affinity for cyanide, and is therefore useful in the treatment of cyanide poisoning. In cases of accidental ingestion, administration of a nitrite (such as amyl nitrite) can be used to deliberately oxidise hemoglobin and raise methemoglobin levels, restoring the functioning of cytochrome oxidase.