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The knowledge of rectal administration is highest among groups of users of alcohol, stimulants and opioids, where over 30% of users are aware of it. [6] The reasons for rectal administration are largely the same as with medicinal drugs: Bypassing the first-pass effect, fast onset, and a relatively high bioavailability with some drugs. [7]
Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. [25]
Sclerotherapy: injection into the submucosal layer or retro rectal space with 5% phenol, 30% hypertonic saline or 25% glucose and perianal cerclage. [5] Human fibrin glue sealant applied endoscopically. [5] [8] Injection of botulinum toxin injection into the external anal sphincter, [5] [8] (a treatment for dyssynergic defecation / anismus).
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The inability to belch can cause bloating, pain, gurgling in the neck and chest and excessive flatulence as built-up air seeks an alternate exit route. ... A Botox injection resolved their ...
Anal bleeding, anal pain, painful defecation. [5] Visual Exam, Digital Rectal Exam, Anoscopy, Exam under anesthesia if pain is not tolerated. [6] Non-Surgical Therapy: High Fiber Diet (25g/day for women and 38g/day for men), [7] Stool softeners, [6] increased water intake to 64oz or more daily, [7] regular exercise and bowel habits, [7] topical ...
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