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Phosphoglycerate kinase (EC 2.7.2.3) (PGK 1) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP : 1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP. Like all kinases it is a transferase.
This step is the enzymatic transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP by phosphoglycerate kinase, forming ATP and 3-phosphoglycerate. At this step, glycolysis has reached the break-even point: 2 molecules of ATP were consumed, and 2 new molecules have now been synthesized.
5230 18655 Ensembl ENSG00000102144 ENSMUSG00000062070 UniProt P00558 P09411 RefSeq (mRNA) NM_000291 NM_008828 RefSeq (protein) NP_000282 NP_032854 Location (UCSC) Chr X: 77.91 – 78.13 Mb Chr X: 105.23 – 105.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phosphoglycerate kinase 1 is an enzyme that in humans is encoded by the PGK1 gene. Interactive pathway map Click on genes ...
In enzymology, a phosphoglycerate kinase (GTP) (EC 2.7.2.10) is an enzyme that catalyzes the chemical reaction. GTP + 3-phospho-D-glycerate GDP + 3-phospho-D-glyceroyl phosphate. Thus, the two substrates of this enzyme are GTP and 3-phospho-D-glycerate, whereas its two products are GDP and 3-phospho-D-glyceroyl phosphate.
1,3-Bisphosphoglyceric acid (1,3-Bisphosphoglycerate or 1,3BPG) is a 3-carbon organic molecule present in most, if not all, living organisms.It primarily exists as a metabolic intermediate in both glycolysis during respiration and the Calvin cycle during photosynthesis. 1,3BPG is a transitional stage between glycerate 3-phosphate and glyceraldehyde 3-phosphate during the fixation/reduction of ...
Substrate-level phosphorylation exemplified with the conversion of ADP to ATP. Substrate-level phosphorylation is a metabolism reaction that results in the production of ATP or GTP supported by the energy released from another high-energy bond that leads to phosphorylation of ADP or GDP to ATP or GTP (note that the reaction catalyzed by creatine kinase is not considered as "substrate-level ...
2,3-BPG is formed from 1,3-BPG by the enzyme BPG mutase.It can then be broken down by 2,3-BPG phosphatase to form 3-phosphoglycerate.Its synthesis and breakdown are, therefore, a way around a step of glycolysis, with the net expense of one ATP per molecule of 2,3-BPG generated as the high-energy carboxylic acid-phosphate mixed anhydride bond is cleaved by 2,3-BPG phosphatase.
Triglycerides are built from three fatty acids, esterified onto each of three hydroxy groups of glycerol, which is derived from glycerol 3-phosphate.In mammals, glycerol 3-phosphate is usually synthesized through glycolysis, a metabolic pathway that degrades glucose into fructose 1,6-bisphosphate and then into two molecules of dihydroxyacetone phosphate, which beget glycerol 3-phosphate and ...