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Roth's spots, also known as Litten spots or the Litten sign, [1] are non-specific red lesions with white or pale centres, seen on the retina of the eye and although traditionally associated with infective endocarditis, can occur in a number of other conditions including hypertension, diabetes, collagen vascular disease, extreme hypoxia, leukemia and HIV.
Moritz Roth (25 December 1839, in Basel – 4 November 1914, in Gottlieben am Untersee) was a Swiss pathologist remembered for describing Roth's spots. He studied medicine at Würzburg , Göttingen , Berlin and Basel, where he received his doctorate in 1864.
Litten's sign is a clinical sign in which cotton wool spots are seen on fundoscopic examination of the retina in patients with infective endocarditis. [ 1 ] The sign is named after Moritz Litten .
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Gatja Helgart Rothe (March 15, 1935 – August 3, 2007) was a German-American artist known for her printmaking, especially mezzotint.She was also a draftswoman and painter.
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