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The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes until each chromosome is properly attached to the ...
Much remains to be explained about spindle checkpoint signaling and the contribution of other spindle checkpoint assembly proteins such as Bub1, BubR1, and Bub3. BubR1 and Bub3 can also form complexes with Cdc20, but it remains to be seen if these proteins facilitate Cdc20 binding to Open Mad2.
The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene [5] [6] in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase.
The G 2-M checkpoint occurs between the G 2 and M phases. The spindle checkpoint occurs during the M phase. Key cyclins associated with each phase are shown. Cell cycle checkpoints are control mechanisms in the eukaryotic cell cycle which ensure its proper progression.
Mad1 is a non-essential protein which in yeast has a function in the spindle assembly checkpoint (SAC). [1] This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells from starting anaphase until the spindle is built up.
Whereas structural centromeric proteins (such as CENP-B), remain stably localized throughout mitosis (including during telophase), the spindle checkpoint components are assembled on the kinetochore in high concentrations in the absence of microtubules, and their concentrations decrease as the number of microtubules attached to the kinetochore ...
Bub3 is a protein involved with the regulation of the Spindle Assembly Checkpoint (SAC); though BUB3 is non-essential in yeast, it is essential in higher eukaryotes. As one of the checkpoint proteins, Bub3 delays the irreversible onset of anaphase through direction of kinetochore localization during prometaphase [5] to achieve biorientation. In ...
10459 71890 Ensembl ENSG00000116670 ENSMUSG00000029003 UniProt Q9UI95 Q9D752 RefSeq (mRNA) NM_001127325 NM_006341 NM_027985 NM_001305420 RefSeq (protein) NP_001120797 NP_006332 NP_001292349 NP_082261 Location (UCSC) Chr 1: 11.67 – 11.69 Mb Chr 4: 148.13 – 148.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mitotic spindle assembly checkpoint protein MAD2B is a protein that in ...