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Oligodendrocytes are a type of glial cell, non-neuronal cells in the central nervous system.They arise during development from oligodendrocyte precursor cells (OPCs), [8] which can be identified by their expression of a number of antigens, including the ganglioside GD3, [9] [10] [11] the NG2 chondroitin sulfate proteoglycan, and the platelet-derived growth factor-alpha receptor subunit (PDGF ...
Oligodendrocyte progenitor cells (OPCs), also known as oligodendrocyte precursor cells, NG2-glia, O2A cells, or polydendrocytes, are a subtype of glia in the central nervous system named for their essential role as precursors to oligodendrocytes and myelin. [1] They are typically identified in the human by co-expression of PDGFRA and CSPG4.
Only the resident oligodendrocyte precursor cells seem to keep this ability once the nervous system matures. Glial cells are known to be capable of mitosis . By contrast, scientific understanding of whether neurons are permanently post-mitotic , [ 28 ] or capable of mitosis, [ 29 ] [ 30 ] [ 31 ] is still developing.
In this latest study, the researchers used a toxin from the venom of a green mamba snake to identify and locate a receptor protein, M1R, on oligodendrocyte precursor cells (OPCs), which fail to ...
50913 Ensembl ENSG00000205927 ENSMUSG00000039830 UniProt Q13516 Q9EQW6 RefSeq (mRNA) NM_005806 NM_016967 RefSeq (protein) NP_005797 NP_058663 Location (UCSC) Chr 21: 33.03 – 33.03 Mb Chr 16: 91.02 – 91.03 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor encoded by the OLIG2 gene ...
Myelin is formed by oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system.Therefore, the first stage of myelinogenesis is often defined as the differentiation of oligodendrocyte progenitor cells (OPCs) or Schwann cell progenitors into their mature counterparts, [4] followed by myelin formation around axons.
These can arise from the tripotential glial restricted precursor cells (GRP), but not from the bipotential O2A/OPC (oligodendrocyte, type 2 astrocyte precursor, also called Oligodendrocyte progenitor cell) cells. Type 2: Antigenically A2B5 +, GFAP +, FGFR3 −, Ran 2 −.
Single-cell omics is a powerful tool that has been used to identify different subpopulations of oligodendrocyte progenitor cells (OPCs) and mature oligodendrocytes in mouse models which were previously undefined. [32]