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TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). [6] In regulating MMPs, TIMP1 plays a crucial role in extracellular matrix (ECM) composition, wound healing, [7] and pregnancy. [8] [9] [10] The dysregulated activity of TIMP1 has been implicated in cancer. [11]
Index inducer or just inducer predictably induce metabolism via a given pathway and are commonly used in prospective clinical drug-drug interaction studies. [2]Strong, moderate, and weak inducers are drugs that decreases the AUC of sensitive index substrates of a given metabolic pathway by ≥80%, ≥50% to <80%, and ≥20% to <50%, respectively.
CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. [5] It is an LU domain and belongs to the LY6/uPAR/alpha-neurotoxin protein family. [6] CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor.
Gene regulation works using operators and repressors in bacteria. Gene Regulation can be summarized by the response of the respective system: Inducible systems - An inducible system is off unless there is the presence of some molecule (called an inducer) that allows for gene expression. The molecule is said to "induce expression".
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.
Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. [ 5 ] [ 6 ] [ 7 ] CISH orthologs [ 8 ] have been identified in most mammals with sequenced genomes. CISH controls T cell receptor (TCR) signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia ...
DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. [ 5 ] [ 6 ] It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. [ 6 ]
54206 74155 Ensembl ENSG00000116285 ENSMUSG00000028967 UniProt Q9UJM3 Q99JZ7 RefSeq (mRNA) NM_018948 NM_133753 NM_001356323 RefSeq (protein) NP_061821 NP_598514 NP_001343252 Location (UCSC) Chr 1: 8 – 8.03 Mb Chr 4: 150.94 – 150.95 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is ...