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"Link Between Long Telomeres and Long Life Is a Tall Tale, Study Finds". The New York Times. ISSN 0362-4331 "Long Telomeres, the Endcaps on DNA, Not the Fountain of Youth Once Thought — Scientists May Now Know Why". www.hopkinsmedicine.org; HannibalRodriguez (2019-08-15).
During DNA replication, DNA polymerase cannot replicate the sequences present at the 3' ends of the parent strands. This is a consequence of its unidirectional mode of DNA synthesis: it can only attach new nucleotides to an existing 3'-end (that is, synthesis progresses 5'-3') and thus it requires a primer to initiate replication.
DNA polymerase's ability to slide along the DNA template allows increased processivity. There is a dramatic increase in processivity at the replication fork. This increase is facilitated by the DNA polymerase's association with proteins known as the sliding DNA clamp. The clamps are multiple protein subunits associated in the shape of a ring.
The two major protein complexes that bind to telomeric DNA in S. cerevisiae are: [citation needed] the Cdc13-Stn1-Ten1 (CST) complex, which binds the single-stranded DNA (ssDNA) of the 3' G-rich overhang at the end of the telomere, and; the Rif1-Rif2-Rap1 complex, which binds the double-stranded DNA (dsDNA) preceding the 3' overhang.
DNA polymerase gamma is the enzyme that replicates mitochondrial DNA. A mouse mutant with a defect in this DNA polymerase is only able to replicate its mitochondrial DNA inaccurately, so that it sustains a 500-fold higher mutation burden than normal mice. These mice showed no clear features of rapidly accelerated aging. [55]
Telomerase, also called terminal transferase, [1] is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each end of the chromosomes of most eukaryotes. Telomeres protect the end of the chromosome from DNA damage or from fusion with neighbouring ...
The "Garden State" has the fifth-longest life expectancy in the US, according to the CDC data. In its 2023 American Community Survey one-year estimates, the Census Bureau said 92.8% of residents ...
Hayflick describes three phases in the life of normal cultured cells. At the start of his experiment he named the primary culture "phase one". Phase two is defined as the period when cells are proliferating; Hayflick called this the time of "luxuriant growth".