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Barbiturate overdose may occur by accident or purposefully in an attempt to cause death. [3] The toxic effects are additive to those of alcohol and benzodiazepines. [3] The lethal dose varies with a person's tolerance and how the drug is taken. [3] The effects of barbiturates occur via the GABA neurotransmitter. [2]
When a person ages, the body becomes less able to rid itself of barbiturates. As a result, people over the age of 65 are at higher risk of experiencing the harmful effects of barbiturates, including drug dependence and accidental overdose. [19] When barbiturates are taken during pregnancy, the drug passes through the placenta to the fetus.
Management of barbiturate dependence involves considering the affected person's age, comorbidity and the pharmacological pathways of barbiturates. [3] Psychological addiction to barbiturates can develop quickly. The patients will then have a strong desire to take any barbiturate-like drug.
One of the most well-known consequences of maternal opioid use during pregnancy is the risk of neonatal abstinence syndrome (NAS). NAS occurs when the newborn experiences withdrawal symptoms after birth due to exposure to opioids in the womb. Maternal opioid use during pregnancy can also have long-term effects on the child's development.
"We call this the honeymoon period, because most women feel well, they are over the nausea, but not so big they feel uncomfortable," Dr. Myra J. Wick, an OB-GYN and author of the comprehensive ...
Pregnancy over the age of 50 has become possible for more women because of advances in assisted reproductive technology, in particular egg donation. Typically, a woman's fecundity ends with menopause , which, by definition, is 12 consecutive months without any menstrual flow at all.
Women’s bodies go through many changes in menopause and the years leading up to it, known as perimenopause. This natural step in the aging process marks the end of the reproductive years. In ...
[8] [7] Use during pregnancy may result in harm to the fetus. [9] Primidone is an anticonvulsant of the barbiturate class; [7] however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital. [10] The drug’s other active metabolite is phenylethylmalonamide (PEMA).