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Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t 1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, [ 2 ] so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy.
Alitretinoin, or 9-cis-retinoic acid, is a form of vitamin A. It is also used in medicine as an antineoplastic (anti-cancer) agent developed by Ligand Pharmaceuticals. It is a first generation retinoid. Ligand gained Food and Drug Administration (FDA) approval for alitretinoin in February 1999.
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Chicago’s “failed approaches…have brought trauma to communities across the city.” More from National Review. Chicago Aldermen Grill Mayor Lightfoot over Refusal to Deploy National Guard Widely
A 12-year-old shot was shot in the back and a CTA bus driver attacked within 20 minutes and less than half a mile apart in the Loop last Saturday night. The attack of the bus driver and videos of ...
Once a doctor decides a patient is a candidate for isotretinoin, [10] they counsel the patient to ensure they understand the drug and the potential side effects. Once the patient signs the necessary paperwork, their doctor will give them a patient ID number, ID card, and program educational materials.
Teens who stomped coyote to death face unlawful hunting charges, more Officers cited the juveniles, all age 16 and 17, and officials said they are slated to appear in Cook County court on Feb. 26 ...