Search results
Results From The WOW.Com Content Network
The major mucins secreted – MUC5AC and MUC5B - are large polymers that give the mucus its rheologic or viscoelastic properties. [7] [4] MUC5AC is the main gel-forming mucin secreted by goblet cells, in the form of threads and thin sheets. MUC5B is a polymeric protein secreted from submucosal glands and some goblet cells, and this is in the ...
Mucins (/ ˈ m juː s ɪ n /) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. [1] Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. [1]
The two main components of the gel are mucins and water, with the mucins forming the backbone of the mucous. [4] Mucin originates from the mucus secretions from submaxillary glands, which are salivary glands that are located under the floor of the mouth. The secreted mucin assists in digestion by coating the bolus such that it travels easily ...
At that point in the reaction, which is defined as gel point, the system loses fluidity and viscosity becomes very large. The onset of gelation, or gel point, is accompanied by a sudden increase in viscosity. [3] This "infinite" sized polymer is called the gel or network, which does not dissolve in the solvent, but can swell in it. [4]
Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin 2 in the lower gastrointestinal tract, and mucin 5AC in the respiratory tract. [1] The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under ...
In vivo, hyaluronic acid forms randomly kinked coils that entangle to form a hyaluronan network, slowing diffusion and forming a diffusion barrier that regulates transport of substances between cells. For example, hyaluronan helps partition plasma proteins between vascular and extravascular spaces, which affects solubility of macromolecules in ...
74180 Ensembl ENSG00000117983 ENSMUSG00000066108 UniProt Q9HC84 n/a RefSeq (mRNA) NM_002458 NM_028801 RefSeq (protein) NP_002449 n/a Location (UCSC) Chr 11: 1.22 – 1.26 Mb Chr 7: 141.39 – 141.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene and by the Muc5b gene in the mouse. It is one of the five gel ...
17831 Ensembl ENSG00000198788 ENSMUSG00000025515 UniProt Q02817 n/a RefSeq (mRNA) NM_002457 NM_023566 RefSeq (protein) NP_002448 n/a Location (UCSC) Chr 11: 1.07 – 1.11 Mb Chr 7: 141.28 – 141.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. Function This gene ...