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Breast cancer is the most common cancer in women worldwide, and can, rarely, also occur in men. There are many different types of breast cancer, of which triple-negative breast cancer is one of ...
Triple-negative is sometimes used as a surrogate term for basal-like. [2] Triple-negative breast cancer comprises 15–20% of all breast cancer cases [3] and affects more young women or women with a mutation in the BRCA1 gene than other breast cancers. [4] Triple-negative breast cancers comprise a very heterogeneous group of cancers.
3. "The current standard for treating patients with clinical stage 2 or 3 triple-negative breast cancer is to administer chemotherapy in addition to immunotherapy prior to surgery. This ...
Sacituzumab govitecan is indicated for the treatment of adults with metastatic triple-negative breast cancer who received at least two prior therapies for metastatic disease; [11] people with unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) who have received two or more prior systemic therapies, at least one of them for metastatic disease; [14] and for people ...
Conversely, triple negative cancer (i.e. no positive receptors), lacking targeted treatments, now has a comparatively poor prognosis. [42] [43] Androgen receptor is expressed in 80-90% of ER+ breast cancers and 40% of "triple negative" breast cancers. Activation of androgen receptors appears to suppress breast cancer growth in ER+ cancer while ...
Triple negative breast cancer, in particular, has a worse prognosis and can be difficult to treat. There are few targeted therapies like there are for estrogen positive breast cancers, she says.
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