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Megaloblastic anemia is a type of macrocytic anemia. An anemia is a red blood cell defect that can lead to an undersupply of oxygen. [1] Megaloblastic anemia results from inhibition of DNA synthesis during red blood cell production. [2] When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M ...
Despite the larger size of the red blood cells, individuals with this condition typically have normal red blood cell function. Causes of macrocytosis may include: Megaloblastic anemia due to deficiency or abnormal metabolism of vitamin B 12 or folate Poor dietary intake, including due to strict veganism; Increased requirements; Pernicious anemia
[1] [2] It is the main and most common cause of vitamin B 12 deficiency anemia in developed countries, [2] and is characterized by a triad of symptoms: Anemia with bone marrow promegaloblastosis (megaloblastic anemia). This is due to the inhibition of DNA synthesis (specifically purines and thymidine).
The size, shape and other characteristics of the red blood cells often provide clues to a possible etiology of the anemia. Other blood tests may be done as indicated to look for potential causes ...
Lack of vitamin B12 can cause megaloblastic anemia—a condition characterized by larger than normal red blood cells in a smaller than normal amount. This causes fatigue, paleness in the skin ...
Folate-deficiency anemia (also known as dietary folate-deficiency anemia) is a condition that develops when the body does not have the adequate supply of folic acid available that is needed for the production of new healthy blood cells. [13] Nutritional megaloblastic anemia: D51.1, D52.0, D53.1: 29507: D000749
Megaloblastic anemia, the most common cause of macrocytic anemia, is due to a deficiency of either vitamin B 12, folic acid, or both. [81] Deficiency in folate or vitamin B 12 can be due either to inadequate intake or insufficient absorption. Folate deficiency normally does not produce neurological symptoms, while B 12 deficiency does.
The presence of hypersegmented neutrophils is an important diagnostic feature of megaloblastic anaemias. Hypersegmentation can also be seen in many other conditions but with relatively less diagnostic significance. Hypersegmentation can sometimes be difficult to assert since interobserver variation is high and segmentation may vary with race.