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Pernicious anemia, or Addison's anemia, is an autoimmune disease which decreases red blood cell count, caused by the body's inability to properly absorb vitamin B12. It can cause diarrhea, pale ...
Pernicious anemia is the most common cause of vitamin B 12 deficiency anemia in adults, which results from malabsorption of vitamin B 12 due to a lack or loss of intrinsic factor. [ 2 ] [ 8 ] There are relatively few studies which have assessed the impact of haematological measures in response to B 12 supplementation.
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [ 8 ]
Most adults need 2.4 micrograms of vitamin B12 a day, although the numbers are slightly higher during pregnancy and breastfeeding. Causes of vitamin B12 deficiency There are a few reasons why ...
Adults need about 2.4 micrograms of B12 a day (that much can be found in one portion of salmon, canned tuna or ground beef), with pregnant and nursing women needing slightly more (2.6 and 2.8 mcg ...
A second major cause is an age-related decline in stomach acid production (achlorhydria), because acid exposure frees protein-bound vitamin. [12] For the same reason, people on long-term antacid therapy, using proton-pump inhibitors , [ 13 ] H 2 blockers or other antacids are at increased risk.