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DNA origami was the cover story of Nature on March 16, 2006. [3] Since then, DNA origami has progressed past an art form and has found a number of applications from drug delivery systems to uses as circuitry in plasmonic devices; however, most commercial applications remain in a concept or testing phase. [4]
DNA origami structures can be designed with specific attachment sites for other nanoscale components, such as nanoparticles, fluorophores, or proteins. By measuring the distances between these components on the origami structures, researchers can perform precise distance measurements at the nanoscale through atomic force microscopy (AFM) and ...
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In contrast, the SNA structure can be synthesized independent of nucleic acid sequence and hybridization, instead their synthesis relies upon chemical bond formation between nanoparticles and DNA ligands. Furthermore, DNA origami uses DNA hybridization interactions to realize a final structure, whereas SNAs and other forms of three-dimensional ...
As a research fellow at Caltech, Rothemund has developed a technique to manipulate and fold strands of DNA known as DNA origami. Eventually, Rothemund hopes that self-assembly techniques could be used to create a "programming language for molecules, just as we have programming languages for computers."
Rothemund's DNA origami contains a long strand which folding is assisted by several short strands. This method allowed forming much larger structures than formerly possible, and which are less technically demanding to design and synthesize. [7] DNA origami was the cover story of Nature on March 15, 2006. [13]
Yui Mok - WPA Pool/Getty Images. Princess Anne secured the top spot, yet again, with 217 royal engagements and a 2.4% increase from 2023, according to the report.November was her busiest month ...
A geometrical model of a DNA tetrahedron described in Goodman, 2005. [10] Models of this type are useful for ensuring that tertiary structure constraints do not cause excessive strain to the molecule. Geometrical models of nucleic acids are used to predict tertiary structure. This is important because designed nucleic acid complexes usually ...