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Proton-pump inhibitors have largely superseded the H 2-receptor antagonists, a group of medications with similar effects but a different mode of action, and heavy use of antacids. [3] A potassium-competitive acid blocker (PCAB) revaprazan was marketed in Korea as an alternative to a PPI.
A derivative of timoprazole, omeprazole, was discovered in 1979, and was the first of a new class of drug that control acid secretion in the stomach, a proton pump inhibitor (PPI). [11] [12] Addition of 5-methoxy-substitution to the benzimidazole moiety of omeprazole was also made and gave the compound much more stability at neutral pH. [6]
Pages in category "Proton-pump inhibitors" The following 18 pages are in this category, out of 18 total. This list may not reflect recent changes. A. Azeloprazole; D.
Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. [9] It can be taken by mouth or by injection into a vein . [ 1 ] [ 10 ] It is also available in the fixed-dose combination medication omeprazole/sodium bicarbonate as Zegerid [ 11 ] [ 12 ] and as Konvomep.
Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. [5] It works by inactivating (H+/K+)-ATPase function in the stomach. [9] [5] The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. [10] It is available as a generic medication.
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
It is a proton pump inhibitor (PPI), used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [5] Its effectiveness is similar to that of other PPIs. [6] It is taken by mouth. [4] Onset is over a few hours and effects last up to a couple of days. [4]
Several anti-ulcer dosing regimens that combine antibiotics and proton pump inhibitors (PPI) to treat helicobacter pylori (H. pylori) induced peptic ulcer disease (PUD). The role of antibiotic in the therapies is to eradicate H. pylori, while the action of PPI is to reduce gastric acid secretion. The anti-ulcer dosing regimens generally repair ...