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Oxytocin is a peptide hormone and neuropeptide normally produced in the hypothalamus and released by the posterior pituitary. [4] Present in animals since early stages of evolution, in humans it plays roles in behavior that include social bonding, love, reproduction, childbirth, and the period after childbirth.
The oxytocin receptor, also known as OXTR, is a protein which functions as receptor for the hormone and neurotransmitter oxytocin. [4] [5] In humans, the oxytocin receptor is encoded by the OXTR gene [6] [7] which has been localized to human chromosome 3p25. [8] Evolutionary tree of the oxytocin, vasotocin, mesotocin and isotocin receptors and ...
In 1950, Geoffrey Harris and Barry Cross outlined the oxytocin pathway by studying oxytocin release in response to electrical stimulation. [24] In 1974, Walters and Hatton investigated the effect of water dehydration by electrically stimulating the supraoptic nucleus—the hypothalamic center responsible for the release of vasopressin. [ 24 ]
Testosterone is converted to 5-DHT by 5alpha-reductase, usually with in the target tissues of 5-DHT because of the need for high concentrations of 5-dht to produce the physiological effects. Aldosterone: mineralocorticoid: adrenal cortex (zona glomerulosa) MR: Increase blood volume by reabsorption of sodium in kidneys (primarily)
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone that is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where ...
Here hypothalamic neurosecretory cells release factors to the blood. Some of these factors (releasing hormones), released at the hypothalamic median eminence, control the secretion of pituitary hormones, while others (the hormones oxytocin and vasopressin) are released directly into the blood.
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Mature peptide hormones then travel through the blood to all of the cells of the body, where they interact with specific receptors on the surfaces of their target cells. Some neurotransmitters are secreted and released in a similar fashion to peptide hormones, and some " neuropeptides " may be used as neurotransmitters in the nervous system in ...