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Glutathione (GSH, / ˌ ɡ l uː t ə ˈ θ aɪ oʊ n /) is an organic compound with the chemical formula HOCOCH(NH 2)CH 2 CH 2 CONHCH(CH 2 SH)CONHCH 2 COOH. It is an antioxidant in plants , animals , fungi , and some bacteria and archaea .
Glutathione synthetase (GSS) (EC 6.3.2.3) is the second enzyme in the glutathione (GSH) biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine, to form glutathione. [2] Glutathione synthetase is also a potent antioxidant. It is found in many species including bacteria, yeast, mammals, and plants. [3]
CoA + glutathione + NADP + CoA-glutathione + NADPH + H + The 3 substrates of this enzyme are CoA , glutathione , and NADP + , whereas its 3 products are CoA-glutathione , NADPH , and H + . This enzyme belongs to the family of oxidoreductases , specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor.