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Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine.Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury.
Acetaminophen (paracetamol, Tylenol) can cause liver damage in dogs. The toxic dose is 150 mg/kg. [174] Ibuprofen * can cause gastrointestinal irritation, stomach ulcers, and kidney damage in dogs. [175] Naproxen (Aleve)* has a long half-life in dogs and can cause gastrointestinal irritation, anemia, melena (digested blood in feces), and vomiting.
The reason some dogs develop kidney failure following ingestion of grapes and raisins is not known. [3] Types of grapes involved include both seedless and seeded, store-bought and homegrown, and grape pressings from wineries. [4] A mycotoxin is suspected to be involved, but none has been found in grapes or raisins ingested by affected dogs. [5]
Protein in excess of these levels is metabolized and leads to an increase of the glomerular filtration rate, and increased urea excretion in the urine, with no evidence of damage to the kidneys. [34] However, addition of protein past these requirements is not recommended, although the NRC has not quantified a safe upper limit. [6] Considering ...
Treatment of an infected dog is difficult, involving an attempt to poison the healthy worm with arsenic compounds without killing the weakened dog, and may not succeed. Prevention is recommended via the use of heartworm prophylactics , which contain a compound that kills the larvae immediately upon infection without harming the dog.
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In addition to wheat gluten, products containing rice protein have also been contaminated with melamine. Natural Balance Pet Foods recalled two products on 16 April due to kidney damage associated with melamine contamination despite the products not containing wheat gluten. [55] Melamine has also been implicated in corn gluten in South Africa. [56]
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