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Multiple system atrophy (MSA) is a rare neurodegenerative disorder [1] characterized by tremors, slow movement, muscle rigidity, postural instability (collectively known as parkinsonism), autonomic dysfunction and ataxia.
They include multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Dementia with Lewy bodies (DLB), may or may not be part of the PD spectrum, but it is increasingly recognized as the second-most common type of neurodegenerative dementia after Alzheimer's disease.
Multiple system atrophy, which Russell also said he was experiencing, is a progressive neurodegenerative disorder that impacts how a person moves, as well as their blood pressure and digestion ...
While Parkinson's disease accounts for 80% of all Parkinsonism cases, other conditions — multiple system atrophy or corticobasal degeneration — can also cause the symptoms.
Such "primary" dysautonomias are distinguished from secondary dysautonomias, where the dysfunction of the autonomic nervous system is believed to be caused by another disease (e.g. diabetes). [2] Diseases categorized as primary autonomic failure usually include pure autonomic failure and multiple system atrophy.
Pure autonomic failure originates from peripheral autonomic nervous system lesions. [6] The diagnosis of pure autonomic failure relies on the absence of other neurologic abnormalities, specifically Parkinsonism, cognitive impairment, cerebellar ataxia, or tremors, and on compatible clinical features of subtle, progressive pan autonomic failure ...
Upper motor neuron lesions occur in the brain or the spinal cord as the result of stroke, multiple sclerosis, traumatic brain injury, cerebral palsy, atypical parkinsonisms, multiple system atrophy, and amyotrophic lateral sclerosis.
multiple system atrophy; Alzheimer's disease; ALS; semantic or logopenic variant primary progressive aphasia; structural lesion suggestive of focal cause; granulin mutation or reduced plasma progranulin levels; TDP-43 or fused in sarcoma (FUS) mutations [20] The diagnostic criteria for clinical use may result in a misdiagnosis of other tau ...