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Atypical squamous cells ... AGC, formerly AGUS, is a term for atypical glandular cells of undetermined significance. [12] Renamed AGC to avoid confusion with ASCUS. [1]
ThinPrep pap smear with group of normal cervical cells on left and HPV-infected cells showing features typical of koilocytes: enlarged (x2 or x3) nuclei and hyperchromasia. A koilocyte is a squamous epithelial cell that has undergone a number of structural changes, which occur as a result of infection of the cell by human papillomavirus (HPV). [1]
Rates for high-grade squamous intraepithelial lesions (median, 0.5%) and atypical squamous cells have changed little. [32] Abnormal results are reported according to the Bethesda system. [33] They include: [31] Atypical squamous cells (ASC) Atypical squamous cells of undetermined significance (ASC-US) Atypical squamous cells – cannot exclude ...
A squamous intraepithelial lesion (SIL) is an abnormal growth of epithelial cells on the surface of the cervix, commonly called squamous cells. This condition can lead to cervical cancer , but can be diagnosed using a Pap smear or a colposcopy .
In other age groups, a Pap test alone can suffice unless they have been diagnosed with atypical squamous cells of undetermined significance (ASC-US). [133] Co-testing with a Pap test and HPV test is recommended because it decreases the rate of false-negatives.
A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. [1] [2] [3] Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer.
D. Squamous cell carcinoma, infiltrating the stroma (middle and left in image), and HSIL (right in image) Epithelial dysplasia , a term becoming increasingly referred to as intraepithelial neoplasia , is the sum of various disturbances of epithelial proliferation and differentiation as seen microscopically.
This system provides a uniform way to describe abnormal epithelial cells and determine specimen quality, thus providing clear guidance for clinical management. These abnormalities were classified as squamous or glandular and then further classified by the stage of dysplasia: atypical cells, mild, moderate, severe, and carcinoma. [13]