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AKT can have a number of downstream effects such as activating CREB, [2] inhibiting p27, [3] localizing FOXO in the cytoplasm, [3] activating PtdIns-3ps, [4] and activating mTOR [3] which can affect transcription of p70 or 4EBP1. [3] There are many known factors that enhance the PI3K/AKT pathway including EGF, [5] shh, [2] IGF-1, [2] insulin ...