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Fibroblast growth factor 21 (FGF-21) is a protein that in mammals is encoded by the FGF21 gene. [5] [6] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19.
A mitogenic growth factor activity was found in pituitary extracts by Armelin in 1973 [14] and further work by Gospodarowicz as reported in 1974 described a more defined isolation of proteins from cow brain extract which, when tested in a bioassay that caused fibroblasts to proliferate, led these investigators to apply the name "fibroblast ...
Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. [5] [6] [7] The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to Fgf8. [8]
Several bioactive peptides and structural proteins were reported to be cleaved by FAP, such as neuropeptide Y (NPY), Peptide YY, Substance P (SP), and B-type natriuretic peptide (BNP), [13] human fibroblast growth factor 21 (FGF-21), human alpha2 antiplasmin and denatured collagen I and III. NPY, FGF-21 and alpha2 antiplasmin are considered to ...
A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation. [1] Usually it is a secreted protein or a steroid hormone.
2255 14165 Ensembl ENSG00000070193 ENSMUSG00000021732 UniProt O15520 O35565 RefSeq (mRNA) NM_004465 NM_008002 RefSeq (protein) NP_004456 NP_032028 Location (UCSC) Chr 5: 44.3 – 44.39 Mb Chr 13: 118.81 – 118.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene. Function The protein encoded by this ...