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Common adverse effects include diarrhea, nausea, and abdominal pain. [16] It has a small risk of causing low blood sugar. [16] High blood lactic acid level is a concern if the medication is used in overly large doses or prescribed in people with severe kidney problems. [23] [24] Metformin is a biguanide anti-hyperglycemic agent. [16]
Yes, metformin treatment has been shown to lower risk of heart-related events in people with type 2 diabetes by improving blood fat levels, reducing inflammation, and lowering blood pressure ...
Taking metformin may cause unpleasant side effects like diarrhea, nausea, upset stomach and, in rare cases, lactic acidosis. Don’t double up on metformin if you miss a dose.
Metformin lowers the synthesis of glucose in liver and absorption of glucose from intestines. It also acquires an antilipolytic effect which reduces free fatty acid concentration. It is proved in many trials that Metformin can normalize menstrual function and raise the chance of ovulation. [33] [34]
No effect on blood pressure; No detrimental effect on low-density lipoprotein; Lower risk of gastrointestinal side effects than metformin; Convenient dosing; Cause an average of 2–5 kg weight gain; Increase the risk of hypoglycemia; Glyburide increases risk of hypoglycemia slightly more compared to glimepiride and glipizide; Metformin
This can affect your appetite and food cravings to support weight loss. These types of meds are especially helpful for people with insulin resistance or type 2 diabetes. Gut microbiome effects.