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Metformin is more commonly associated with gastrointestinal adverse effects than most other antidiabetic medications. [46] [77] The most serious potential adverse effect of metformin is lactic acidosis; this complication is rare, and seems to be related to impaired liver or kidney function.
While it was once “just” a medication for people with type 2 diabetes, metformin is now thought of as a “wonder drug with multiple potentials,” says David Cutler, M.D., a family medicine ...
Yes, metformin treatment has been shown to lower risk of heart-related events in people with type 2 diabetes by improving blood fat levels, reducing inflammation, and lowering blood pressure ...
Metformin is an example of a class of medicine called biguanides. [34] The medication works by reducing the new creation of glucose from the liver and by reducing absorption of sugar from food. [34] In addition, the medication also works to help increase the effects of insulin on muscle cells, which take in glucose. [35]
No effect on blood pressure; No detrimental effect on low-density lipoprotein; Lower risk of gastrointestinal side effects than metformin; Convenient dosing; Cause an average of 2–5 kg weight gain; Increase the risk of hypoglycemia; Glyburide increases risk of hypoglycemia slightly more compared to glimepiride and glipizide; Metformin
Prepare for potential side effects. Taking metformin may cause unpleasant side effects like diarrhea, nausea, and an upset stomach. Taking it with food can reduce the risk.
Metformin is one of the most common first-line medications for type 2 diabetes. Side effects of diabetes medications can include weight loss. Side effects of diabetes medications can include ...
The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. [15] Metformin was shown to cause increased levels of GDF15. This increase mediates the effect of body weight loss by metformin. [16]