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Phage therapy is the use of bacteriophages to treat bacterial infections. Bacteriophage treatment offers a possible alternative to conventional antibiotic treatments for bacterial infection. [55] It is conceivable that, although bacteria can develop resistance to phages, the resistance might be easier to overcome than resistance to antibiotics.
Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.
Bacteriophages were heralded as a potential treatment for diseases such as typhoid and cholera, but their promise was forgotten with the development of penicillin. Since the early 1970s, bacteria have continued to develop resistance to antibiotics such as penicillin , and this has led to a renewed interest in the use of bacteriophages to treat ...
Phage therapy – treatment using bacteriophage viruses that infect and kill bacteria to combat bacterial infections. Pre-exposure prophylaxis – taking medication taken before potential exposure to prevent infectious disease. Post-exposure prophylaxis – taking medication taken after potential exposure to prevent infectious disease.
Bacterial and Bacteriophage Genetics: An Introduction. ... Studies of the infection of E. coli B with the ... [French; Treatment of the wounds of war by the ...
Some bacteria are even resistant to multiple antibiotics and antibacterial drugs. [6] This problem prompted researchers to look towards other possible regulators of bacterial growth, like Autographiviridae bacteriophages. [5] This type of treatment is referred to as phage therapy. Phage therapy is effective against drug-resistant bacteria ...
The bacteriophage life cycle involves the viruses injecting their genome into bacterial cells, inserting those genes into the bacterial genome, and hijacking the bacteria's machinery to produce hundreds of new phages until the cell bursts open to release them for additional infections. Typically, bacteriophages are only capable of infecting a ...
A rapid killing rate of bacteria has also been observed upon administration of endolysins due to the enzymatic mechanism, as have synergistic effects among different endolysins and in combination with antibiotics, improving treatment outcomes of bacterial infections. [3]