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Scientist Otto Warburg, whose research activities led to the formulation of the Warburg hypothesis for explaining the root cause of cancer.. The Warburg hypothesis (/ ˈ v ɑːr b ʊər ɡ /), sometimes known as the Warburg theory of cancer, postulates that the driver of carcinogenesis (cancer formation) is insufficient cellular respiration caused by insult (damage) to mitochondria. [1]
The Warburg effect has been much studied, but its precise nature remains unclear, which hampers the beginning of any work that would explore its therapeutic potential. [7] Otto Warburg postulated this change in metabolism is the fundamental cause of cancer, [8] a claim now known as the Warburg hypothesis.
Signed drawings of Otto Warburg by Manuel Rosenberg for the Cincinnati Post 1922. Otto Heinrich Warburg (German pronunciation: [ˈɔto ˈvaːɐ̯bʊʁk] ⓘ, / ˈ v ɑːr b ɜːr ɡ /; 8 October 1883 – 1 August 1970) was a German physiologist, medical doctor, and Nobel laureate.
Original description of the method appeared in 1941. [2] The method is named for its creators, the German cancer researcher Otto Heinrich Warburg, Nobel Prize winner, and his employee Walter Christian of the Kaiser Wilhelm Institute for Biology in Berlin.
In the absence of hypoxic conditions (i.e. physiological levels of oxygen), cancer cells preferentially convert glucose to lactate, according to Otto H. Warburg, who believed that aerobic glycolysis was the key metabolic change in cancer cell malignancy. The "Warburg effect" was later coined to describe this metabolic shift. [6]
The Warburg effect, named for Otto Heinrich Warburg, may refer to: Warburg effect (embryology) Warburg effect inversion; Warburg effect (oncology)
A former college dean who dedicated years of her life to researching a cure for cancer was gunned down on a walking trail near campus last week and her killer is still on the loose, leaving a ...
This phenomenon was first described in 1930 by Otto Warburg and is referred to as the Warburg effect. The Warburg hypothesis claims that cancer is primarily caused by dysfunctionality in mitochondrial metabolism, rather than because of the uncontrolled growth of cells. A number of theories have been advanced to explain the Warburg effect.