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Platelets collected by using apheresis at an American Red Cross donation center. Not all platelet transfusions use platelets collected by automated apheresis. The platelets can also be separated from donations of whole blood collected in a traditional blood donation, but there are several advantages to separating the platelets at the time of collection.
The yield is normally the equivalent of between six and ten random platelet concentrates. Quality control demands the platelets from apheresis be equal to or greater than 3.0 × 10 11 in number and have a pH of equal to or greater than 6.2 in 90% of the products tested and must be used within five days. Leukapheresis – leukocytes (white blood ...
Platelets can be produced either from whole blood or by apheresis. [1] They keep for up to five to seven days. [1] Platelet transfusions came into medical use in the 1950s and 1960s. [1] [5] It is on the World Health Organization's List of Essential Medicines.
Platelets collected by using apheresis at an American Red Cross donation center. Apheresis is a blood donation method where the blood is passed through an apparatus that separates out one particular constituent and returns the remainder to the donor.
A normal platelet count ranges from 150 to 400 x10 9 /L, but these patients can have platelet counts well below 50 x 10 9 /L. These low platelet counts are associated with an increased bleeding risk. Generally, platelet transfusions are given at a threshold of 10 x10 9 /L in order to increase the number of circulating platelets.
Platelets are either isolated from collected units of whole blood and pooled to make a therapeutic dose, or collected by platelet apheresis: blood is taken from the donor, passed through a device which removes the platelets, and the remainder is returned to the donor in a closed loop. The industry standard is for platelets to be tested for ...
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Reconstituted whole blood: Diluted whole blood with either saline or plasma to a hematocrit equal to patients own hematocrit. [7] Replaces the prime volume in the apheresis circuit with reconstituted whole blood. [7] Reduces risk for anemia (see adverse events) 5% Albumin: Isotonic solutions Replaces the prime volume in the circuit with 5% albumin.