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In vitro, monocytes can differentiate into dendritic cells by adding the cytokines granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4. [19] Such monocyte-derived cells do, however, retain the signature of monocytes in their transcriptome and they cluster with monocytes and not with bona fide dendritic cells. [20]
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Monocytes, the largest type of white blood cell, share the "vacuum cleaner" (phagocytosis) function of neutrophils, but are much longer lived as they have an extra role: they present pieces of pathogens to T cells so that the pathogens may be recognized again and killed. This causes an antibody response to be mounted.
Agranulocytes include lymphocytes and monocytes. The condition of having too few white blood cells is leukopenia, while having too many is leukocytosis. There are individual terms for the lack or overabundance of specific types of white blood cells. The number of white blood cells in circulation is commonly increased in the incidence of ...
These cords contain half of the mouse body's monocytes as a reserve so that, after tissue injury, these monocytes can move in and aid locally sourced monocytes in wound healing. [ 1 ] Erythrocytes pass through the cords of Billroth before entering the sinusoids.
The monoblast is the first stage of monocyte-macrophage maturation. The developmental stages of the monoblast are: CFU-GM (pluripotential hemopoietic stem cell or hemocytoblast) -> monoblast -> promonocyte-> monocyte-> macrophage/dendritic cell. During their development, monocytes are present in large packs in all of the lymph nodes in the body ...
The red pulp also acts as a large reservoir for monocytes. These monocytes are found in clusters in the Billroth's cords (red pulp cords). The population of monocytes in this reservoir is greater than the total number of monocytes present in circulation. They can be rapidly mobilised to leave the spleen and assist in tackling ongoing infections ...
The first stage of the myeloid lineage is a granulocyte - monocyte progenitor (GMP), still an oligopotent progenitor, which then develops into unipotent cells that will later on form a population of granulocytes, as well as a population of monocytes. The first unipotent cell in granulopoiesis is a myeloblast. [5]