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The Cox maze procedure, also known as maze procedure, is a type of heart surgery for atrial fibrillation. "Maze" refers to the series of incisions arranged in a maze -like pattern in the atria . Today, various methods of minimally invasive maze procedures, collectively named minimaze procedures , are used.
Budiodarone (ATI-2042) is an antiarrhythmic agent and chemical analog of amiodarone that is currently being studied in clinical trials.Amiodarone is considered the most effective antiarrhythmic drug available, [1] [2] [3] but its adverse side effects, including hepatic, pulmonary and thyroid toxicity as well as multiple drug interactions, [4] are discouraging its use.
Atrial fibrillation is associated with an increased risk of heart failure, dementia, and stroke. [3] [12] It is a type of supraventricular tachycardia. [14] Atrial fibrillation frequently results from bursts of tachycardia that originate in muscle bundles extending from the atrium to the pulmonary veins. [15]
With those caveats in mind, it can be said that reported short-term freedom from atrial fibrillation following the radiofrequency ("Wolf") procedure ranges from 67% to 91% [8] [9] [11] with longer-term results in a similar range, but limited primarily to patients with paroxysmal atrial fibrillation. [19] [20]
Clinical trials have compared dronedarone to placebo and to amiodarone, for its ability to reduce atrial fibrillation, to reduce mortality overall and from cardiac causes, and for its adverse effects, including excess mortality. [5] [9] Dronedarone is a non-iodinated class III anti-arrhythmic drug which helps patients return to normal sinus rhythm.
A new expert report, published in the journal Stroke, reviews the latest research and explains that three common cardiovascular diseases in adults — heart failure, atrial fibrillation (AFib ...
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