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  2. Allopregnanolone - Wikipedia

    en.wikipedia.org/wiki/Allopregnanolone

    The 21-hydroxylated derivative of this compound, tetrahydrodeoxycorticosterone, is an endogenous inhibitory neurosteroid with similar properties to those of allopregnanolone, and the 3β-methyl analogue of allopregnanolone, ganaxolone, is under development to treat epilepsy and other conditions, including post-traumatic stress disorder.

  3. Neurosteroid - Wikipedia

    en.wikipedia.org/wiki/Neurosteroid

    These neurosteroids exert inhibitory actions on neurotransmission.They act as positive allosteric modulators of the GABA A receptor (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, [10] prosocial, [11] antiaggressive, [12] prosexual, [11] sedative, pro-sleep, [13] cognitive and memory-impairing, [citation ...

  4. Neurosteroidogenesis inhibitor - Wikipedia

    en.wikipedia.org/wiki/Neurosteroidogenesis_inhibitor

    A neurosteroidogenesis inhibitor is a drug that inhibits the production of endogenous neurosteroids.Neurosteroids include the excitatory neurosteroids pregnenolone sulfate, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S), and the inhibitory neurosteroids allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol, among others. [1]

  5. List of investigational antidepressants - Wikipedia

    en.wikipedia.org/wiki/List_of_investigational...

    This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. Specific indications include major depressive disorder , treatment-resistant depression , dysthymia , bipolar depression , and postpartum depression , among others.

  6. The Most Common Antidepressants (& How to Get Them) - AOL

    www.aol.com/most-common-antidepressants-them...

    Antidepressants are most commonly prescribed for people who have major depressive disorder (MDD). MDD is described as feeling depressed, moody or sad all, every day, for at least two weeks.

  7. Breakthrough antidepressants with fewer side effects could ...

    www.aol.com/finance/breakthrough-antidepressants...

    Ketamine’s antidepressant effects are part of what prompted researchers to explore other drugs that target glutamate—like the venerable cough suppressant dextromethorphan found in Robitussin ...

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