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They cannot be reliably differentiated from low grade papillary urothelial carcinomas using cytology, [1] and their diagnosis (vis-a-vis low grade papillary urothelial carcinoma) has a poor inter-rater reliability. [2] Pathologic grading and staging tumors are: graded by the degree of cellular atypia (G1->G3), and staged: [citation needed ...
The 1973 WHO grading system for transitional cell carcinomas (papilloma, G1, G2 or G3) is most commonly used despite being superseded by the 2004 WHO [14] grading for papillary types (papillary neoplasm of low malignant potential [PNLMP], low grade, and high grade papillary carcinoma). High-grade carcinoma typically displays more pleomorphism ...
Most NMIBC tumors start as low-grade papillary (finger-like, projecting into the bladder) tumors. [67] Mutations in cell growth pathways are common. Most common are mutations that activate FGFR3 (present in up to 80% of NMIBC tumors). [67]
English: Papillary urothelial carcinoma (low-grade) showing thickened and slightly atypical urothelium with maintained polarity. H&E Stain. Date: 18 April 2018: Source:
The most common type is papillary urothelial carcinoma. [1] [5] Risk factors suggested include prolonged irritations of the urethra due to urinary catheterization, chronic inflammation due to infection, radiation, diverticula of the urethra, and urethral strictures. [1]
Urothelial carcinoma 0.7 to 2.8% [12] Umbrella cells are usually present in low-grade tumors [13] Frequently branching fibrovascular cores [13] Frequently fusing of papillae [13] Not recommended [1] Small-cell carcinoma 0.3–2% [14] [15] [notes 1] Small blue cells with scant cytoplasm [1] High nucleus/cytoplasm ratio [1] "salt and pepper ...