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The enzyme DNA topoisomerase IIα prominently appears along the chromosome axis as part of the scaffold. [3] In mitosis, it is concentrated at the centromeres and the axis along the chromosome arms. It is thought that the protein has a role in untangling the DNA as the loops become more concentrated along the axis during the condensation of the ...
Chromosome scaffold has important role to hold the chromatin into compact chromosome. Chromosome scaffold is made of proteins including condensin , topoisomerase IIα and kinesin family member 4 (KIF4) [ 27 ] Chromosome scaffold constituent proteins are also called scaffold protein.
Transcription is terminated (III) followed by dissociation of the transcription complex (IV) The term S/MAR (scaffold/matrix attachment region), otherwise called SAR (scaffold-attachment region), or MAR (matrix-associated region), are sequences in the DNA of eukaryotic chromosomes where the nuclear matrix attaches.
Many aspects of transcription are controlled by chemical modification on the histone proteins, known as the histone code. Chromosome scaffold has important role to hold the chromatin into compact chromosome. Chromosome scaffold is made of proteins including condensin, topoisomerase IIα and kinesin family member 4 (KIF4) [7]
They play vital roles in regulating processes like nucleosome remodeling, DNA replication, RNA synthesis and processing, nuclear transport, steroid hormone action and interphase/mitosis transition. [1] Scaffold proteins, DNA polymerase, Heterochromatin Protein 1 and Polycomb are common non-histone proteins. This classification group also ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 22 February 2025. DNA molecule containing genetic material of a cell This article is about the DNA molecule. For the genetic algorithm, see Chromosome (genetic algorithm). Chromosome (10 7 - 10 10 bp) DNA Gene (10 3 - 10 6 bp) Function A chromosome and its packaged long strand of DNA unraveled. The DNA's ...
This gene encodes a DNA-binding protein that has specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there are conflicting views as to whether this protein is a component of chromatin, the nuclear matrix, or both.
CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene. [ 5 ] [ 6 ] It is a part of the CCR4-Not complex, which deadenylates mRNAs . [ 7 ]