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Sensory and protective functions. Hair follicles have nerve endings, making them sensitive to touch and vibrations. Hair follicle sensations help people detect external stimuli and respond appropriately. Hair also provides a physical barrier that helps protect the skin from environmental damage, UV radiation, and mechanical injury.
The regenerative abilities of mammalian hair follicles are facilitated by the proliferation of hair follicle stem cells (HFSCs), which reside in specialized niches within the skin.
The hair follicle is an organ found in mammalian skin. [1] It resides in the dermal layer of the skin and is made up of 20 different cell types, each with distinct functions. The hair follicle regulates hair growth via a complex interaction between hormones, neuropeptides, and immune cells. [1]
Hair follicles, as one of the important skin appendages, plays an irreplaceable role in skin function and in the process of skin regeneration. The hair follicle is a unique skin structure found in mammals, and is essentially a small organ formed by the interaction between epidermis and dermis.
For example, the hair follicle acts as a sensory organ and immunologic sentinel for the skin. Hairs detect mechanical stimuli above the surface of the skin, and the slightest bend in a hair...
The hair follicle (HF) is a highly conserved sensory organ associated with the immune response against pathogens, thermoregulation, sebum production, angiogenesis, neurogenesis and wound...
Hair follicles generate hair and help to provide epithelial stem cells used for wound repair. Besides the cosmetic concerns of hair color, growth, and distribution, hair plays a vital role in thermoregulation, tactile sensation, and ultraviolet (UV) radiation protection.
Hair Follicle Receptors (Lanceolate Receptors) In guard hairs and down hairs, the nerve endings run in parallel to the hair shaft and give rise to the lanceolate terminals immediately below the sebaceous glands. In an electronmicroscopic picture, they are seen in a circumferential array or palisade (Fig. 2) .
These regulate diverse HF functions, including growth, stem cell, and immune status. Organ culture of human scalp HFs can identify novel functions of neuromediators. The human hair follicle (HF) is an exquisitely hormone-sensitive mini-organ that undergoes cyclical remodeling.
In this review, we provide an overview of the structure of a hair follicle, explain the role of the follicle in regulating the microenvironment of skin and the impact on wound healing, explore individual cell types of interest for regenerative medicine, and cover several applications of keratin-based biomaterials.